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Enantioselective C(sp(3))–C(sp(3)) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis
Cross-coupling of two alkyl fragments is an efficient method to produce organic molecules rich in sp(3)-hybridized carbon centers, which are attractive candidate compounds in drug discovery. Enantioselective C(sp(3))–C(sp(3)) coupling is challenging, especially of alkyl electrophiles without an acti...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610379/ https://www.ncbi.nlm.nih.gov/pubmed/33380741 http://dx.doi.org/10.1038/s41557-020-00576-z |