Cargando…
Photocatalytic proximity labelling of MCL-1 by a BH3 ligand
Ligand-directed protein labelling allows the introduction of diverse chemical functionalities onto proteins without the need for genetically encoded tags. Here we report a method for the rapid labelling of a protein using a ruthenium-bipyridyl (Ru(II)(bpy)(3))-modified peptide designed to mimic an i...
Autores principales: | Beard, Hester A., Hauser, Jacob R., Walko, Martin, George, Rachel M., Wilson, Andrew J., Bon, Robin S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610391/ https://www.ncbi.nlm.nih.gov/pubmed/33763603 http://dx.doi.org/10.1038/s42004-019-0235-z |
Ejemplares similares
-
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
por: Lee, Erinna F., et al.
Publicado: (2008) -
The MCL-1 BH3 Helix is an Exclusive MCL-1 inhibitor and Apoptosis Sensitizer
por: Stewart, Michelle L., et al.
Publicado: (2010) -
Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling
por: Nakane, Keita, et al.
Publicado: (2022) -
Increased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma
por: Jacob, Maureen, et al.
Publicado: (2023) -
Designed BH3 Peptides with High Affinity and Specificity
for Targeting Mcl-1 in Cells
por: Foight, Glenna Wink, et al.
Publicado: (2014)