Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation

The calcium release activated calcium (CRAC) channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. Upon activation, STIM1 C-terminus changes from an inactive, tight to an active, extended conformation. A coiled-coil (CC) clamp involving the CC1 and CC3 domains is e...

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Detalles Bibliográficos
Autores principales: Rathner, Petr, Fahrner, Marc, Cerofolini, Linda, Grabmayr, Herwig, Horvath, Ferdinand, Krobath, Heinrich, Gupta, Agrim, Ravera, Enrico, Fragai, Marco, Bechmann, Matthias, Renger, Thomas, Luchinat, Claudio, Romanin, Christoph, Müller, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610458/
https://www.ncbi.nlm.nih.gov/pubmed/33106661
http://dx.doi.org/10.1038/s41589-020-00672-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610458/
https://www.ncbi.nlm.nih.gov/pubmed/33106661
http://dx.doi.org/10.1038/s41589-020-00672-8

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