Cargando…

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation

The calcium release activated calcium (CRAC) channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. Upon activation, STIM1 C-terminus changes from an inactive, tight to an active, extended conformation. A coiled-coil (CC) clamp involving the CC1 and CC3 domains is e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rathner, Petr, Fahrner, Marc, Cerofolini, Linda, Grabmayr, Herwig, Horvath, Ferdinand, Krobath, Heinrich, Gupta, Agrim, Ravera, Enrico, Fragai, Marco, Bechmann, Matthias, Renger, Thomas, Luchinat, Claudio, Romanin, Christoph, Müller, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610458/ https://www.ncbi.nlm.nih.gov/pubmed/33106661 http://dx.doi.org/10.1038/s41589-020-00672-8

Ejemplares similares

Resonance assignment of coiled-coil 3 (CC3) domain of human STIM1
por: Gupta, Agrim, et al.
Publicado: (2021)

Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade
por: Höglinger, Carmen, et al.
Publicado: (2021)

STIM Proteins: An Ever-Expanding Family
por: Grabmayr, Herwig, et al.
Publicado: (2020)

Swing‐out opening of stromal interaction molecule 1
por: Horvath, Ferdinand, et al.
Publicado: (2023)

Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
por: Maltan, Lena, et al.
Publicado: (2023)

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus
por: Derler, Isabella, et al.
Publicado: (2018)

S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
por: Yu, Tao, et al.
Publicado: (2023)

The many states of STIM1
por: Fahrner, Marc, et al.
Publicado: (2021)

The STIM1/Orai signaling machinery
por: Fahrner, Marc, et al.
Publicado: (2013)

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state
por: Fahrner, Marc, et al.
Publicado: (2018)

Mapping interactions between the CRAC activation domain and CC1 regulating the activity of the ER Ca(2+) sensor STIM1
por: Shrestha, Nisha, et al.
Publicado: (2022)

Gated regulation of CRAC channel ion selectivity by STIM1
por: McNally, Beth A., et al.
Publicado: (2012)

Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function
por: Muik, Martin, et al.
Publicado: (2012)

Science CommuniCa(2+)tion Developing Scientific Literacy on Calcium: The Involvement of CRAC Currents in Human Health and Disease
por: Humer, Christina, et al.
Publicado: (2022)

Orientation of immobilized antigens on common surfaces by a simple computational model: Exposition of SARS-CoV-2 Spike protein RBD epitopes
por: Cerofolini, Linda, et al.
Publicado: (2020)

(1)H-detected solid-state NMR of proteins entrapped in bioinspired silica: a new tool for biomaterials characterization
por: Ravera, Enrico, et al.
Publicado: (2016)

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1
por: Covington, Elizabeth D., et al.
Publicado: (2010)

Regulation of Orai1/STIM1 mediated I(CRAC) by intracellular pH
por: Gavriliouk, D., et al.
Publicado: (2017)

Atomic structural details of a protein grafted onto gold nanoparticles
por: Giuntini, Stefano, et al.
Publicado: (2017)

Structural characterization of a protein adsorbed on aluminum hydroxide adjuvant in vaccine formulation
por: Cerofolini, Linda, et al.
Publicado: (2019)

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
por: Muik, Martin, et al.
Publicado: (2011)

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
por: Stathopulos, Peter B., et al.
Publicado: (2013)

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
por: Yamashita, Megumi, et al.
Publicado: (2017)

STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain
por: Korzeniowski, Marek K., et al.
Publicado: (2016)

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)
por: Fahrner, Marc, et al.
Publicado: (2014)

Characterization of the Conjugation Pattern in Large Polysaccharide–Protein Conjugates by NMR Spectroscopy
por: Giuntini, Stefano, et al.
Publicado: (2017)

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
por: Penna, Aubin, et al.
Publicado: (2008)

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits
por: Yen, Michelle, et al.
Publicado: (2018)

IMPContact: An Interhelical Residue Contact Prediction Method
por: Fang, Chao, et al.
Publicado: (2020)

Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions
por: Humer, Christina, et al.
Publicado: (2022)

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions
por: Tiffner, Adéla, et al.
Publicado: (2020)

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
por: Derler, Isabella, et al.
Publicado: (2013)

In this issue of Channels: Special issue on STIM and Orai
por: Romanin, Christoph
Publicado: (2013)

Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity
por: Cerofolini, Linda, et al.
Publicado: (2016)

Evaluation of the Higher Order Structure of Biotherapeutics Embedded in Hydrogels for Bioprinting and Drug Release
por: Rizzo, Domenico, et al.
Publicado: (2021)

Molecular mechanisms of STIM/Orai communication
por: Derler, Isabella, et al.
Publicado: (2016)

Real-Time Insights into Biological Events: In-Cell Processes and Protein-Ligand Interactions
por: Cerofolini, Linda, et al.
Publicado: (2019)

The elementary unit of store-operated Ca(2+) entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions
por: Luik, Riina M., et al.
Publicado: (2006)

A protocol to automatically calculate homo-oligomeric protein structures through the integration of evolutionary constraints and NMR ambiguous contacts
por: Sala, Davide, et al.
Publicado: (2019)

The action of selective CRAC channel blockers is affected by the Orai pore geometry
por: Derler, Isabella, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_0ioa6a3kgs06bdh708egad3mql