Evolutionary dynamics of neoantigens in growing tumors

Cancers accumulate mutations that lead to neoantigens, novel peptides that elicit an immune response, and consequently undergo evolutionary selection. Here we establish how negative selection shapes the clonality of neoantigens in a growing cancer, by constructing a mathematical model of neoantigen...

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Detalles Bibliográficos
Autores principales: Lakatos, Eszter, Williams, Marc J., Schenck, Ryan O., Cross, William C. H., Househam, Jacob, Zapata, Luis, Werner, Benjamin, Gatenbee, Chandler, Robertson-Tessi, Mark, Barnes, Chris P., Anderson, Alexander R. A., Sottoriva, Andrea, Graham, Trevor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610467/
https://www.ncbi.nlm.nih.gov/pubmed/32929288
http://dx.doi.org/10.1038/s41588-020-0687-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610467/
https://www.ncbi.nlm.nih.gov/pubmed/32929288
http://dx.doi.org/10.1038/s41588-020-0687-1

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