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Evolutionary dynamics of neoantigens in growing tumors
Cancers accumulate mutations that lead to neoantigens, novel peptides that elicit an immune response, and consequently undergo evolutionary selection. Here we establish how negative selection shapes the clonality of neoantigens in a growing cancer, by constructing a mathematical model of neoantigen...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610467/ https://www.ncbi.nlm.nih.gov/pubmed/32929288 http://dx.doi.org/10.1038/s41588-020-0687-1 |