Genomic encoding of transcriptional burst kinetics

Mammalian gene expression is inherently stochastic(1,2)resulting in discrete bursts of RNA molecules synthesised from each allele(3–7). Although known to be regulated by promoters and enhancers, it is unclear how cis-regulatory sequences encode transcriptional burst kinetics. Characterization of tra...

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Detalles Bibliográficos
Autores principales: Larsson, Anton, Johnsson, Per, Hagemann-Jensen, Michael, Hartmanis, Leonard, Faridani, Omid R., Reinius, Björn, Segerstolpe, Åsa, Rivera, Chloe M., Ren, Bing, Sandberg, Rickard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610481/
https://www.ncbi.nlm.nih.gov/pubmed/30602787
http://dx.doi.org/10.1038/s41586-018-0836-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610481/
https://www.ncbi.nlm.nih.gov/pubmed/30602787
http://dx.doi.org/10.1038/s41586-018-0836-1

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