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Genomic encoding of transcriptional burst kinetics
Mammalian gene expression is inherently stochastic(1,2)resulting in discrete bursts of RNA molecules synthesised from each allele(3–7). Although known to be regulated by promoters and enhancers, it is unclear how cis-regulatory sequences encode transcriptional burst kinetics. Characterization of tra...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610481/ https://www.ncbi.nlm.nih.gov/pubmed/30602787 http://dx.doi.org/10.1038/s41586-018-0836-1 |