Allosteric Site on SHIP2 Identified Through Fluorescent Ligand Screening and Crystallography: A Potential New Target for Intervention

[Image: see text] Src homology 2 domain-containing inositol phosphate phosphatase 2 (SHIP2) is one of the 10 human inositol phosphate 5-phosphatases. One of its physiological functions is dephosphorylation of phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P(3). It is therefore a therapeutic...

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Detalles Bibliográficos
Autores principales: Whitfield, Hayley, Hemmings, Andrew M., Mills, Stephen J., Baker, Kendall, White, Gaye, Rushworth, Stuart, Riley, Andrew M., Potter, Barry V. L., Brearley, Charles A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610569/
https://www.ncbi.nlm.nih.gov/pubmed/33724834
http://dx.doi.org/10.1021/acs.jmedchem.0c01944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610569/
https://www.ncbi.nlm.nih.gov/pubmed/33724834
http://dx.doi.org/10.1021/acs.jmedchem.0c01944

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