Targeted Perturb-seq enables genome-scale genetic screens in single cells

The transcriptome contains rich information on molecular, cellular, and organismal phenotypes. However, experimental and statistical limitations constrain sensitivity and throughput of genetic screening with single-cell transcriptomics readout. To overcome these limitations, we introduce targeted Pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Schraivogel, Daniel, Gschwind, Andreas R., Milbank, Jennifer H., Leonce, Daniel R., Jakob, Petra, Mathur, Lukas, Korbel, Jan O., Merten, Christoph, Velten, Lars, Steinmetz, Lars M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610614/
https://www.ncbi.nlm.nih.gov/pubmed/32483332
http://dx.doi.org/10.1038/s41592-020-0837-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610614/
https://www.ncbi.nlm.nih.gov/pubmed/32483332
http://dx.doi.org/10.1038/s41592-020-0837-5

Ejemplares similares