Activation of naïve CD4(+) T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4(+) T cells

The cytokine IL-6 controls the survival, proliferation and effector characteristics of lymphocytes through activation of the transcription factors STAT1 and STAT3. While STAT3 activity is an ever-present feature of IL-6 signaling in CD4(+) T cells, prior T-cell receptor activation limits the IL-6 co...

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Detalles Bibliográficos
Autores principales: Twohig, Jason P., Figueras, Ana Cardus, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Soria, Alicia Derrac, Lewis, Myles J., Townsend, Michael J., Millrine, David, Li, Jasmine, Hill, David G., Fernandez, Javier Uceda, Liu, Xiao, Szomolay, Barbara, Pepper, Christopher J., Taylor, Philip R., Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M., Jones, Gareth W., Jones, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610646/
https://www.ncbi.nlm.nih.gov/pubmed/30890796
http://dx.doi.org/10.1038/s41590-019-0350-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610646/
https://www.ncbi.nlm.nih.gov/pubmed/30890796
http://dx.doi.org/10.1038/s41590-019-0350-0

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