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Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection
The interplay between host and pathogen relies heavily on rapid protein synthesis and accurate protein targeting to ensure pathogen destruction. To gain insight into this dynamic interface, we combined click-chemistry with pulsed stable isotope labeling of amino acids in cell culture (pSILAC-AHA) to...
Autores principales: | Selkrig, Joel, Li, Nan, Hausmann, Annika, Mangan, Matthew S. J., Zietek, Matylda, Mateus, André, Bobonis, Jacob, Sueki, Anna, Imamura, Haruna, El Debs, Bachir, Sigismondo, Gianluca, Florea, Bogdan I., Overkleeft, Herman S., Kopitar-Jerala, Natasa, Turk, Boris, Beltrao, Pedro, Savitski, Mikhail, Latz, Eicke, Hardt, Wolf-Dietrich, Krijgsveld, Jeroen, Typas, Athanasios |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610801/ https://www.ncbi.nlm.nih.gov/pubmed/32514074 http://dx.doi.org/10.1038/s41564-020-0736-7 |
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