Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells

LRRK2 protein is expressed prominently in immune cells, cell types whose contribution to LRRK2-associated genetic Parkinson’s disease (PD) is increasingly being recognised. We investigated the effect of inflammatory stimuli using RAW264.7 murine macrophage cells as model systems. A detailed time cou...

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Detalles Bibliográficos
Autores principales: Nazish, Iqra, Arber, Charles, Piers, Thomas M., Warner, Thomas T., Hardy, John A., Lewis, Patrick A., Pocock, Jennifer M., Bandopadhyay, Rina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610942/
https://www.ncbi.nlm.nih.gov/pubmed/34004238
http://dx.doi.org/10.1016/j.neuint.2021.105070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610942/
https://www.ncbi.nlm.nih.gov/pubmed/34004238
http://dx.doi.org/10.1016/j.neuint.2021.105070

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