Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >90% of cancers. However, any direct causal link between...

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Detalles Bibliográficos
Autores principales: Sharma, Shalu, Mukherjee, Ananda Kishore, Roy, Shuvra Shekhar, Bagri, Sulochana, Lier, Silje, Verma, Meenakshi, Sengupta, Antara, Kumar, Manish, Nesse, Gaute, Prakash, Deo Pandey, Chowdhury, Shantanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611063/
https://www.ncbi.nlm.nih.gov/pubmed/34010660
http://dx.doi.org/10.1016/j.celrep.2021.109154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611063/
https://www.ncbi.nlm.nih.gov/pubmed/34010660
http://dx.doi.org/10.1016/j.celrep.2021.109154

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