Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being associated with ~70% of all gene promoters. CGIs control transcription initiation by conferring nearby promoters with unique chromatin properties. In addition, there are thousands of distal or orphan CGIs (oCGIs) whose fu...

Descripción completa

Detalles Bibliográficos
Autores principales: Pachano, Tomas, Sánchez-Gaya, Víctor, Ealo, Thais, Mariner-Faulí, Maria, Bleckwehl, Tore, Asenjo, Helena G., Respuela, Patricia, Cruz-Molina, Sara, Martín, María Muñoz-San, Haro, Endika, van IJcken, Wilfred F. J., Landeira, David, Rada-Iglesias, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611182/
https://www.ncbi.nlm.nih.gov/pubmed/34183853
http://dx.doi.org/10.1038/s41588-021-00888-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611182/
https://www.ncbi.nlm.nih.gov/pubmed/34183853
http://dx.doi.org/10.1038/s41588-021-00888-x

Ejemplares similares