Plasma Pharmacokinetics of High-Dose Oral versus Intravenous Rifampicin in Patients with Tuberculous Meningitis: a Randomized Controlled Trial

Higher doses of intravenous rifampicin may improve outcomes in tuberculous meningitis but are impractical in high-burden settings. We hypothesized that plasma rifampicin exposures would be similar between oral dosing of 35 mg/kg of body weight and intravenous dosing of 20 mg/kg, which has been propo...

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Detalles Bibliográficos
Autores principales: Wasserman, Sean, Davis, Angharad, Stek, Cari, Chirehwa, Maxwell, Botha, Stephani, Daroowala, Remy, Bremer, Marise, Maxebengula, Mpumi, Koekemoer, Sonya, Goliath, Rene, Jackson, Amanda, Crede, Thomas, Naude, Jonathan, Szymanski, Patryk, Vallie, Yakoob, Moosa, Muhammed S., Wiesner, Lubbe, Black, John, Meintjes, Graeme, Maartens, Gary, Wilkinson, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611291/
https://www.ncbi.nlm.nih.gov/pubmed/33972248
http://dx.doi.org/10.1128/AAC.00140-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611291/
https://www.ncbi.nlm.nih.gov/pubmed/33972248
http://dx.doi.org/10.1128/AAC.00140-21

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