Dissecting OCT4 defines the role of nucleosome binding in pluripotency

Pioneer transcription factors (TFs) such as OCT4 can target silent genes embedded in nucleosome-dense regions. How nucleosome interaction enables TFs to target chromatin and determine cell identity remains elusive. Here, we systematically dissect OCT4 to show that nucleosome binding is encoded withi...

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Detalles Bibliográficos
Autores principales: Roberts, Gareth A., Ozkan, Burak, Gachulincová, Ivana, O’Dwyer, Michael R., Hall-Ponsele, Elisa, Saxena, Manoj, Robinson, Philip J., Soufi, Abdenour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611526/
https://www.ncbi.nlm.nih.gov/pubmed/34354236
http://dx.doi.org/10.1038/s41556-021-00727-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611526/
https://www.ncbi.nlm.nih.gov/pubmed/34354236
http://dx.doi.org/10.1038/s41556-021-00727-5

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