Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer

Inhibitors of apoptosis proteins (IAPs) are intracellular proteins, with important roles in regulating cell death, inflammation, and immunity. Here, we examined the clinical and therapeutic relevance of IAPs in colorectal cancer. We found that elevated expression of cIAP1 and cIAP2 (but not XIAP) si...

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Detalles Bibliográficos
Autores principales: Crawford, Nyree, Stott, Katie J., Sessler, Tamas, McCann, Christopher, McDaid, William, Lees, Andrea, Latimer, Cheryl, Fox, Jennifer P., Munck, Joanne M., Smyth, Tomoko, Shah, Alpesh, Martins, Vanessa, Lawler, Mark, Dunne, Philip D., Kerr, Emma M., McDade, Simon S., Coyle, Vicky M., Longley, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611622/
https://www.ncbi.nlm.nih.gov/pubmed/34389694
http://dx.doi.org/10.1158/1535-7163.MCT-20-1050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611622/
https://www.ncbi.nlm.nih.gov/pubmed/34389694
http://dx.doi.org/10.1158/1535-7163.MCT-20-1050

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