DNAPK Inhibition Preferentially Compromises the Repair of Radiation-induced DNA Double-strand Breaks in Chronically Hypoxic Tumor Cells in Xenograft Models

Radiation-induced DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR) and nonhomologous end joining (NHEJ). Recently, it has been found that chronic tumor hypoxia compromises HR repair of DNA DSBs but activates the NHEJ protein DNAPK. We therefore hypothesized that inhib...

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Detalles Bibliográficos
Autores principales: Jiang, Yanyan, Willmore, Elaine, Wedge, Stephen R., Ryan, Anderson J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611623/
https://www.ncbi.nlm.nih.gov/pubmed/34158348
http://dx.doi.org/10.1158/1535-7163.MCT-20-0857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611623/
https://www.ncbi.nlm.nih.gov/pubmed/34158348
http://dx.doi.org/10.1158/1535-7163.MCT-20-0857

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