The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

Hypoxia-inducible transcription factors (HIFs) are fundamental to the cellular adaptation to low oxygen levels but it is unclear how they interact with chromatin and activate their target genes. Here we use genome-wide mutagenesis to identify genes involved in HIF transcriptional activity, and defin...

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Detalles Bibliográficos
Autores principales: Ortmann, Brian M., Burrows, Natalie, Lobb, Ian T., Arnaiz, Esther, Wit, Niek, Bailey, Peter S. J., Jordon, Louise H., Lombardi, Olivia, Peñalver, Ana, McCaffrey, James, Seear, Rachel, Mole, David R., Ratcliffe, Peter J., Maxwell, Patrick H., Nathan, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611696/
https://www.ncbi.nlm.nih.gov/pubmed/34155378
http://dx.doi.org/10.1038/s41588-021-00887-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611696/
https://www.ncbi.nlm.nih.gov/pubmed/34155378
http://dx.doi.org/10.1038/s41588-021-00887-y

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