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The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes
Hypoxia-inducible transcription factors (HIFs) are fundamental to the cellular adaptation to low oxygen levels but it is unclear how they interact with chromatin and activate their target genes. Here we use genome-wide mutagenesis to identify genes involved in HIF transcriptional activity, and defin...
Autores principales: | Ortmann, Brian M., Burrows, Natalie, Lobb, Ian T., Arnaiz, Esther, Wit, Niek, Bailey, Peter S. J., Jordon, Louise H., Lombardi, Olivia, Peñalver, Ana, McCaffrey, James, Seear, Rachel, Mole, David R., Ratcliffe, Peter J., Maxwell, Patrick H., Nathan, James A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611696/ https://www.ncbi.nlm.nih.gov/pubmed/34155378 http://dx.doi.org/10.1038/s41588-021-00887-y |
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