IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity

Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo.

Detalles Bibliográficos
Autores principales: Ryan, Dylan, Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611773/
https://www.ncbi.nlm.nih.gov/pubmed/34621543
http://dx.doi.org/10.20900/immunometab20210030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611773/
https://www.ncbi.nlm.nih.gov/pubmed/34621543
http://dx.doi.org/10.20900/immunometab20210030

Ejemplares similares