Cargando…
IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity
Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo.
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611773/ https://www.ncbi.nlm.nih.gov/pubmed/34621543 http://dx.doi.org/10.20900/immunometab20210030 |
| _version_ | 1783605303255760896 |
|---|---|
| author | Ryan, Dylan Frezza, Christian |
| author_facet | Ryan, Dylan Frezza, Christian |
| author_sort | Ryan, Dylan |
| collection | PubMed |
| description | Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo. |
| format | Online Article Text |
| id | pubmed-7611773 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-76117732021-10-06 IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity Ryan, Dylan Frezza, Christian Immunometabolism Article Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to promote cytotoxicity and durable anti-tumour responses in vivo. 2021-09-24 /pmc/articles/PMC7611773/ /pubmed/34621543 http://dx.doi.org/10.20900/immunometab20210030 Text en Licensee Hapres, London, United Kingdom. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Ryan, Dylan Frezza, Christian IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity |
| title | IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity |
| title_full | IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity |
| title_fullStr | IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity |
| title_full_unstemmed | IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity |
| title_short | IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity |
| title_sort | il-10-mediated refueling of exhausted t cell mitochondria boosts anti-tumour immunity |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611773/ https://www.ncbi.nlm.nih.gov/pubmed/34621543 http://dx.doi.org/10.20900/immunometab20210030 |
| work_keys_str_mv | AT ryandylan il10mediatedrefuelingofexhaustedtcellmitochondriaboostsantitumourimmunity AT frezzachristian il10mediatedrefuelingofexhaustedtcellmitochondriaboostsantitumourimmunity |