AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia

Acute leukemias are systemic malignancies associated with a dire outcome. Because of low immunogenicity, leukemias display a remarkable ability to evade immune control and are often resistant to checkpoint blockade. Here, we discover that leukemia cells actively establish a suppressive environment t...

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Detalles Bibliográficos
Autores principales: Tirado-Gonzalez, Irene, Descot, Arnaud, Soetopo, Devona, Nevmerzhitskaya, Aleksandra, Schäffer, Alexander, Kur, Ivan-Maximilano, Czlonka, Ewelina, Wachtel, Carolin, Tsoukala, Ioanna, Müller, Luise, Schäfer, Anna-Lena, Weitmann, Maresa, Dinse, Petra, Alberto, Emily, Buck, Michèle C., Landry, Jonathan JM., Baying, Bianka, Slotta-Huspenina, Julia, Roesler, Jenny, Harter, Patrick N., Kubasch, Anne-Sophie, Meinel, Jörn, Elwakeel, Eiman, Strack, Elisabeth, Quang, Christine Tran, Abdel-Wahab, Omar, Schmitz, Marc, Weigert, Andreas, Schmid, Tobias, Platzbecker, Uwe, Benes, Vladimir, Ghysdael, Jacques, Bonig, Halvard, Götze, Katharina S., Rothlin, Carla V., Ghosh, Sourav, Medyouf, Hind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611942/
https://www.ncbi.nlm.nih.gov/pubmed/34103328
http://dx.doi.org/10.1158/2159-8290.CD-20-1378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611942/
https://www.ncbi.nlm.nih.gov/pubmed/34103328
http://dx.doi.org/10.1158/2159-8290.CD-20-1378

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