Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Malignancy and tumour progression are associated with cancer-cell softening. Yet how the biomechanics of cancer cells affects T-cell mediated cytotoxicity and thus the outcomes of adoptive T-cell immunotherapies is unknown. Here, we show that T-cell-mediated cancer-cell killing is hampered for corti...

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Detalles Bibliográficos
Autores principales: Lei, Kewen, Kurum, Armand, Kaynak, Murat, Bonati, Lucia, Han, Yulong, Cencen, Veronika, Gao, Min, Xie, Yu-Qing, Guo, Yugang, Hannebelle, Mélanie T.M., Wu, Yangping, Zhou, Guanyu, Guo, Ming, Fantner, Georg E., Sakar, Mahmut S., Tang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612108/
https://www.ncbi.nlm.nih.gov/pubmed/34873307
http://dx.doi.org/10.1038/s41551-021-00826-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612108/
https://www.ncbi.nlm.nih.gov/pubmed/34873307
http://dx.doi.org/10.1038/s41551-021-00826-6

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