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Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy
Malignancy and tumour progression are associated with cancer-cell softening. Yet how the biomechanics of cancer cells affects T-cell mediated cytotoxicity and thus the outcomes of adoptive T-cell immunotherapies is unknown. Here, we show that T-cell-mediated cancer-cell killing is hampered for corti...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612108/ https://www.ncbi.nlm.nih.gov/pubmed/34873307 http://dx.doi.org/10.1038/s41551-021-00826-6 |