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Quantifying Efficiency Gains of Innovative Designs of Two-Arm Vaccine Trials for COVID-19 Using an Epidemic Simulation Model
Clinical trials of a vaccine during an epidemic face particular challenges, such as the pressure to identify an effective vaccine quickly to control the epidemic, and the effect that time-space-varying infection incidence has on the power of a trial. We illustrate how the operating characteristics o...
Autores principales: | Johnson, Rob, Jackson, Chris, Presanis, Anne, Villar, Sofia S., De Angelis, Daniela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612285/ https://www.ncbi.nlm.nih.gov/pubmed/35096276 http://dx.doi.org/10.1080/19466315.2021.1939774 |
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