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Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9

Nudix hydrolase 9 (NUDT9) is a member of the nucleoside linked to another moiety X (NUDIX) protein superfamily, which hydrolyses a broad spectrum of organic pyrophosphates from metabolic processes. ADP‐ribose (ADPR) has been the only known endogenous substrate accepted by NUDT9 so far. The Ca(2+)‐pe...

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Detalles Bibliográficos
Autores principales: Gattkowski, Ellen, Rutherford, Trevor J., Möckl, Franziska, Bauche, Andreas, Sander, Simon, Fliegert, Ralf, Tidow, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612441/
https://www.ncbi.nlm.nih.gov/pubmed/34189846
http://dx.doi.org/10.1111/febs.16097