Cancer-Associated SF3B1 Mutations Confer a BRCA-Like Cellular Phenotype and Synthetic Lethality to PARP Inhibitors

Mutations in SF3B1 have been identified across several cancer types. This key spliceosome component promotes the efficient mRNA splicing of thousands of genes including those with crucial roles in the cellular response to DNA damage. Here, we demonstrate that depletion of SF3B1 specifically compromi...

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Detalles Bibliográficos
Autores principales: Lappin, Katrina M., Barros, Eliana M., Jhujh, Satpal S., Irwin, Gareth W., McMillan, Hayley, Liberante, Fabio G., Latimer, Cheryl, La Bonte, Melissa J., Mills, Ken I., Harkin, D. Paul, Stewart, Grant S., Savage, Kienan I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Molecular Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612475/
https://www.ncbi.nlm.nih.gov/pubmed/35027467
http://dx.doi.org/10.1158/0008-5472.CAN-21-1843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612475/
https://www.ncbi.nlm.nih.gov/pubmed/35027467
http://dx.doi.org/10.1158/0008-5472.CAN-21-1843

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