Engineering an Efficient and Enantioselective Enzyme for the Morita-Baylis-Hillman Reaction

The combination of computational design and directed evolution could offer a general strategy to create enzymes with new functions. To date, this approach has delivered enzymes for a handful of model reactions. Here we show that new catalytic mechanisms can be engineered into proteins to accelerate...

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Detalles Bibliográficos
Autores principales: Crawshaw, Rebecca, Crossley, Amy E., Johannissen, Linus, Burke, Ashleigh J., Hay, Sam, Levy, Colin, Baker, David, Lovelock, Sarah L., Green, Anthony P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612480/
https://www.ncbi.nlm.nih.gov/pubmed/34916595
http://dx.doi.org/10.1038/s41557-021-00833-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612480/
https://www.ncbi.nlm.nih.gov/pubmed/34916595
http://dx.doi.org/10.1038/s41557-021-00833-9

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