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Engineering an Efficient and Enantioselective Enzyme for the Morita-Baylis-Hillman Reaction
The combination of computational design and directed evolution could offer a general strategy to create enzymes with new functions. To date, this approach has delivered enzymes for a handful of model reactions. Here we show that new catalytic mechanisms can be engineered into proteins to accelerate...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612480/ https://www.ncbi.nlm.nih.gov/pubmed/34916595 http://dx.doi.org/10.1038/s41557-021-00833-9 |