New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

Oligodendrocytes that survive demyelination can remyelinate, including in Multiple Sclerosis (MS), but how they do so is unclear. Here, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also foun...

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Autores principales: Neely, Sarah A, Williamson, Jill M, Klingseisen, Anna, Zoupi, Lida, Early, Jason J, Williams, Anna, Lyons, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612594/
https://www.ncbi.nlm.nih.gov/pubmed/35165460
http://dx.doi.org/10.1038/s41593-021-01009-x
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author Neely, Sarah A
Williamson, Jill M
Klingseisen, Anna
Zoupi, Lida
Early, Jason J
Williams, Anna
Lyons, David A
author_facet Neely, Sarah A
Williamson, Jill M
Klingseisen, Anna
Zoupi, Lida
Early, Jason J
Williams, Anna
Lyons, David A
author_sort Neely, Sarah A
collection PubMed
description Oligodendrocytes that survive demyelination can remyelinate, including in Multiple Sclerosis (MS), but how they do so is unclear. Here, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also found in MS. In contrast, oligodendrocytes generated after demyelination make abundant and correctly targeted sheaths, indicating that they likely also have a better regenerative potential in MS.
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spelling pubmed-76125942022-08-14 New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination Neely, Sarah A Williamson, Jill M Klingseisen, Anna Zoupi, Lida Early, Jason J Williams, Anna Lyons, David A Nat Neurosci Article Oligodendrocytes that survive demyelination can remyelinate, including in Multiple Sclerosis (MS), but how they do so is unclear. Here, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also found in MS. In contrast, oligodendrocytes generated after demyelination make abundant and correctly targeted sheaths, indicating that they likely also have a better regenerative potential in MS. 2022-04-01 2022-02-14 /pmc/articles/PMC7612594/ /pubmed/35165460 http://dx.doi.org/10.1038/s41593-021-01009-x Text en https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
spellingShingle Article
Neely, Sarah A
Williamson, Jill M
Klingseisen, Anna
Zoupi, Lida
Early, Jason J
Williams, Anna
Lyons, David A
New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
title New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
title_full New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
title_fullStr New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
title_full_unstemmed New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
title_short New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
title_sort new oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612594/
https://www.ncbi.nlm.nih.gov/pubmed/35165460
http://dx.doi.org/10.1038/s41593-021-01009-x
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