Genome-protective topoisomerase 2a-dependent G2 arrest requires p53 in hTERT-positive cancer cells

Topoisomerase 2a (Topo2a)-dependent G2 arrest engenders faithful segregation of sister chromatids, yet in certain tumor cell lines where this arrest is dysfunctional, a PKCε-dependent failsafe pathway can be triggered. Here we elaborate on recent advances in understanding the underlying mechanisms a...

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Detalles Bibliográficos
Autores principales: Lockwood, Nicola, Martini, Silvia, Lopez-Pardo, Ainara, Deiss, Katharina, Segeren, Hendrika A., Semple, Robert K., Collins, Ian, Repana, Dimitra, Cobbaut, Mathias, Soliman, Tanya, Ciccarelli, Francesca, Parker, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612711/
https://www.ncbi.nlm.nih.gov/pubmed/35247890
http://dx.doi.org/10.1158/0008-5472.CAN-21-1785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612711/
https://www.ncbi.nlm.nih.gov/pubmed/35247890
http://dx.doi.org/10.1158/0008-5472.CAN-21-1785

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