Sequential enhancer state remodelling defines human germline competence and specification

Germline-soma segregation is a fundamental event during mammalian embryonic development. Here, we establish the epigenetic principles of human primordial germ cell (hPGC) development using in vivo hPGCs and stem cell models recapitulating gastrulation. We show that morphogen-induced remodelling of m...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Walfred W.C., Castillo-Venzor, Aracely, Gruhn, Wolfram H., Kobayashi, Toshihiro, Penfold, Christopher A., Morgan, Michael D., Sun, Dawei, Irie, Naoko, Azim Surani, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612729/
https://www.ncbi.nlm.nih.gov/pubmed/35411086
http://dx.doi.org/10.1038/s41556-022-00878-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612729/
https://www.ncbi.nlm.nih.gov/pubmed/35411086
http://dx.doi.org/10.1038/s41556-022-00878-z

Ejemplares similares