TNF induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport

Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species (mROS), which initiate a signaling cascade to cause pathogenic necrosis of mycobacterium-infected macrophages. Here,...

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Detalles Bibliográficos
Autores principales: Roca, Francisco J., Whitworth, Laura J., Prag, Hiran A., Murphy, Michael P., Ramakrishnan, Lalita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612974/
https://www.ncbi.nlm.nih.gov/pubmed/35737799
http://dx.doi.org/10.1126/science.abh2841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612974/
https://www.ncbi.nlm.nih.gov/pubmed/35737799
http://dx.doi.org/10.1126/science.abh2841

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