CKS1 inhibition reveals vulnerabilities in leukemic stem cells with concomitant protection of healthy hematopoietic stem cells

Acute myeloid leukemia (AML) is an aggressive hematological disorder comprising a hierarchy of quiescent leukemic stem cells (LSCs) and proliferating blasts with limited self-renewal ability. AML has a dismal prognosis, with extremely low two-year survival rates in the poorest cytogenetic risk patie...

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Detalles Bibliográficos
Autores principales: Grey, William, Rio-Machin, Ana, Casado-Izquierdo, Pedro, Grönroos, Eva, Ali, Sara, Miettinen, Juho J., Bewicke-Copley, Findley, Parsons, Alun, Heckman, Caroline A., Swanton, Charles, Cutillas, Pedro, Gribben, John, Fitzgibbon, Jude, Bonnet, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612983/
https://www.ncbi.nlm.nih.gov/pubmed/35731890
http://dx.doi.org/10.1126/scitranslmed.abn3248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612983/
https://www.ncbi.nlm.nih.gov/pubmed/35731890
http://dx.doi.org/10.1126/scitranslmed.abn3248

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