Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8(+) T Cells

Effector CD8(+) T cells rely primarily on glucose metabolism to meet their biosynthetic and functional needs. However, nutritional limitations in the tumor microenvironment can cause T-cell hyporesponsiveness. Therefore, T cells must acquire metabolic traits enabling sustained effector function at t...

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Detalles Bibliográficos
Autores principales: Chowdhury, Snehanshu, Kar, Anwesha, Bhowmik, Debaleena, Gautam, Anupam, Basak, Debashree, Sarkar, Ishita, Ghosh, Puspendu, Sarkar, Deborpita, Deka, Alvina, Chakraborty, Paramita, Mukhopadhyay, Asima, Mehrotra, Shikhar, Basak, Soumen, Paul, Sandip, Chatterjee, Shilpak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Tumor Biology and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613107/
https://www.ncbi.nlm.nih.gov/pubmed/35648389
http://dx.doi.org/10.1158/0008-5472.CAN-21-4052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613107/
https://www.ncbi.nlm.nih.gov/pubmed/35648389
http://dx.doi.org/10.1158/0008-5472.CAN-21-4052

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