Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability

Protein abundance affects the evolution of protein genotypes, but we do not know how it affects the evolution of protein phenotypes. Here we investigate the role of protein abundance on the evolvability of green fluorescent protein (GFP) towards the novel phenotype of cyan fluorescence. We evolve GF...

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Detalles Bibliográficos
Autores principales: Karve, Shraddha, Dasmeh, Pouria, Zheng, Jia, Wagner, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613228/
https://www.ncbi.nlm.nih.gov/pubmed/35798838
http://dx.doi.org/10.1038/s41559-022-01797-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613228/
https://www.ncbi.nlm.nih.gov/pubmed/35798838
http://dx.doi.org/10.1038/s41559-022-01797-w

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