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Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms
The implications of stem cell heterogeneity for disease pathogenesis and therapy are poorly defined. JAK2V617F(+) myeloproliferative neoplasms (MPNs), harboring the same mutation in hematopoietic stem cells (HSCs), display diverse phenotypes, including polycythemia vera (PV), essential thrombocythem...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613297/ https://www.ncbi.nlm.nih.gov/pubmed/33798424 http://dx.doi.org/10.1016/j.stem.2021.02.026 |