MNK2 deficiency potentiates β-cell regeneration via translational regulation

Regenerating pancreatic β-cells is a potential curative approach for diabetes. We previously identified the small molecule CID661578 as a potent inducer of β-cell regeneration, but its target and mechanism of action have remained unknown. We now screened 257 million yeast clones and determined that...

Descripción completa

Detalles Bibliográficos
Autores principales: Karampelias, Christos, Watt, Kathleen, Mattsson, Charlotte L., Ruiz, Ángel Fernández, Rezanejad, Habib, Mi, Jiarui, Liu, Xiaojing, Chu, Lianhe, Locasale, Jason W., Korbutt, Gregory S., Rovira, Meritxell, Larsson, Ola, Andersson, Olov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613404/
https://www.ncbi.nlm.nih.gov/pubmed/35697798
http://dx.doi.org/10.1038/s41589-022-01047-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613404/
https://www.ncbi.nlm.nih.gov/pubmed/35697798
http://dx.doi.org/10.1038/s41589-022-01047-x

Ejemplares similares