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MNK2 deficiency potentiates β-cell regeneration via translational regulation

Regenerating pancreatic β-cells is a potential curative approach for diabetes. We previously identified the small molecule CID661578 as a potent inducer of β-cell regeneration, but its target and mechanism of action have remained unknown. We now screened 257 million yeast clones and determined that...

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Detalles Bibliográficos
Autores principales:	Karampelias, Christos, Watt, Kathleen, Mattsson, Charlotte L., Ruiz, Ángel Fernández, Rezanejad, Habib, Mi, Jiarui, Liu, Xiaojing, Chu, Lianhe, Locasale, Jason W., Korbutt, Gregory S., Rovira, Meritxell, Larsson, Ola, Andersson, Olov
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613404/ https://www.ncbi.nlm.nih.gov/pubmed/35697798 http://dx.doi.org/10.1038/s41589-022-01047-x

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