An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations

The E3 ubiquitin ligase RNF12 plays essential roles during development, and the gene encoding it, RLIM, is mutated in the X-linked human developmental disorder Tonne-Kalscheuer syndrome (TOKAS). Substrates of RNF12 include transcriptional regulators such as the pluripotency-associated transcriptiona...

Descripción completa

Detalles Bibliográficos
Autores principales: Segarra-Fas, Anna, Espejo-Serrano, Carmen, Bustos, Francisco, Zhou, Houjiang, Wang, Feng, Toth, Rachel, Macartney, Thomas, Bach, Ingolf, Nardocci, Gino, Findlay, Greg M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613676/
https://www.ncbi.nlm.nih.gov/pubmed/35857630
http://dx.doi.org/10.1126/scisignal.abm5995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613676/
https://www.ncbi.nlm.nih.gov/pubmed/35857630
http://dx.doi.org/10.1126/scisignal.abm5995

Ejemplares similares