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An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations
The E3 ubiquitin ligase RNF12 plays essential roles during development, and the gene encoding it, RLIM, is mutated in the X-linked human developmental disorder Tonne-Kalscheuer syndrome (TOKAS). Substrates of RNF12 include transcriptional regulators such as the pluripotency-associated transcriptiona...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613676/ https://www.ncbi.nlm.nih.gov/pubmed/35857630 http://dx.doi.org/10.1126/scisignal.abm5995 |