Uterine natural killer cells ace an “A” in education: NKG2A sets up crucial functions at the maternal-fetal interface

I argue here that reproduction was a driving force in the evolution of NK-cell education, which is set by interactions between inhibitory receptors and self MHC. Maternal lymphocytes also interact with allogeneic MHC on fetal trophoblast cells. How the maternal immune system accommodates the semi-al...

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Autor principal: Colucci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613701/
https://www.ncbi.nlm.nih.gov/pubmed/36192118
http://dx.doi.org/10.4049/jimmunol.2200384
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author Colucci, Francesco
author_facet Colucci, Francesco
author_sort Colucci, Francesco
collection PubMed
description I argue here that reproduction was a driving force in the evolution of NK-cell education, which is set by interactions between inhibitory receptors and self MHC. Maternal lymphocytes also interact with allogeneic MHC on fetal trophoblast cells. How the maternal immune system accommodates the semi-allogeneic fetus is a fascinating question. But it may be the wrong question. Tissue lymphocytes, like uterine NK (uNK) cells, do not attack the mismatched fetus and its placenta. Instead, they help the local vasculature to accommodate changes necessary to nourish the fetus. Education of uNK cells, driven by the ancient CD94:NKG2A inhibitory receptor and self MHC, sets them up to deliver these key functions at the maternal-fetal interface. /112
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spelling pubmed-76137012022-10-15 Uterine natural killer cells ace an “A” in education: NKG2A sets up crucial functions at the maternal-fetal interface Colucci, Francesco J Immunol Article I argue here that reproduction was a driving force in the evolution of NK-cell education, which is set by interactions between inhibitory receptors and self MHC. Maternal lymphocytes also interact with allogeneic MHC on fetal trophoblast cells. How the maternal immune system accommodates the semi-allogeneic fetus is a fascinating question. But it may be the wrong question. Tissue lymphocytes, like uterine NK (uNK) cells, do not attack the mismatched fetus and its placenta. Instead, they help the local vasculature to accommodate changes necessary to nourish the fetus. Education of uNK cells, driven by the ancient CD94:NKG2A inhibitory receptor and self MHC, sets them up to deliver these key functions at the maternal-fetal interface. /112 2022-10-15 /pmc/articles/PMC7613701/ /pubmed/36192118 http://dx.doi.org/10.4049/jimmunol.2200384 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
Colucci, Francesco
Uterine natural killer cells ace an “A” in education: NKG2A sets up crucial functions at the maternal-fetal interface
title Uterine natural killer cells ace an “A” in education: NKG2A sets up crucial functions at the maternal-fetal interface
title_full Uterine natural killer cells ace an “A” in education: NKG2A sets up crucial functions at the maternal-fetal interface
title_fullStr Uterine natural killer cells ace an “A” in education: NKG2A sets up crucial functions at the maternal-fetal interface
title_full_unstemmed Uterine natural killer cells ace an “A” in education: NKG2A sets up crucial functions at the maternal-fetal interface
title_short Uterine natural killer cells ace an “A” in education: NKG2A sets up crucial functions at the maternal-fetal interface
title_sort uterine natural killer cells ace an “a” in education: nkg2a sets up crucial functions at the maternal-fetal interface
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613701/
https://www.ncbi.nlm.nih.gov/pubmed/36192118
http://dx.doi.org/10.4049/jimmunol.2200384
work_keys_str_mv AT coluccifrancesco uterinenaturalkillercellsaceanaineducationnkg2asetsupcrucialfunctionsatthematernalfetalinterface

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