Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance

Disease progression and relapse of chronic myeloid leukemia (CML) are caused by therapy resistant leukemia stem cells (LSCs), and cure relies on their eradication. The microenvironment in the bone marrow (BM) is known to contribute to LSC maintenance and resistance. Although leukemic infiltration of...

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Detalles Bibliográficos
Autores principales: Bührer, Elias D., Amrein, Michael A., Forster, Stefan, Isringhausen, Stephan, Schürch, Christian M., Bhate, Salil S., Brodie, Tess, Zindel, Joel, Stroka, Deborah, Sayed, Mohamad Al, Nombela-Arrieta, César, Radpour, Ramin, Riether, Carsten, Ochsenbein, Adrian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613762/
https://www.ncbi.nlm.nih.gov/pubmed/36163264
http://dx.doi.org/10.1038/s41375-022-01682-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613762/
https://www.ncbi.nlm.nih.gov/pubmed/36163264
http://dx.doi.org/10.1038/s41375-022-01682-2

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