A modular XNAzyme cleaves long, structured RNAs under physiological conditions and enables allele-specific gene silencing

Nucleic acid catalysts (ribozymes, DNA- and XNAzymes) cleave target (m)RNAs with high specificity but have shown limited efficacy in clinical application. Here we report on the in vitro evolution and engineering of a highly specific modular RNA endonuclease XNAzyme, FR6_1, composed of 2’-deoxy-2’-fl...

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Detalles Bibliográficos
Autores principales: Taylor, Alexander I., Wan, Christopher J.K., Donde, Maria J., Peak-Chew, Sew-Yeu, Holliger, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613789/
https://www.ncbi.nlm.nih.gov/pubmed/36064973
http://dx.doi.org/10.1038/s41557-022-01021-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613789/
https://www.ncbi.nlm.nih.gov/pubmed/36064973
http://dx.doi.org/10.1038/s41557-022-01021-z

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