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Two-stage penalized regression screening to detect biomarker-treatment interactions in randomized clinical trials

High-dimensional biomarkers such as genomics are increasingly being measured in randomized clinical trials. Consequently, there is a growing interest in developing methods that improve the power to detect biomarker–treatment interactions. We adapt recently proposed two-stage interaction detecting pr...

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Detalles Bibliográficos
Autores principales: Wang, Jixiong, Patel, Ashish, Wason, James M.S., Newcombe, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613856/
https://www.ncbi.nlm.nih.gov/pubmed/33448327
http://dx.doi.org/10.1111/biom.13424