A two-stage drop-the-losers design for time-to-event outcome using a historical control arm

Phase II immuno-oncology clinical trials screen for efficacy an increasing number of treatments. In rare cancers, using historical control data is a pragmatic approach for speeding up clinical trials. The drop-the-losers design allows dropping off ineffective arms at interim analyses. We extended th...

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Detalles Bibliográficos
Autores principales: Abbas, Rachid, Wason, James, Michiels, Stefan, Teuff, Gwénaёl Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613915/
https://www.ncbi.nlm.nih.gov/pubmed/34664352
http://dx.doi.org/10.1002/pst.2168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613915/
https://www.ncbi.nlm.nih.gov/pubmed/34664352
http://dx.doi.org/10.1002/pst.2168

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