Active site remodelling of a cyclodipeptide synthase redefines substrate scope

Cyclodipeptide synthases (CDPSs) generate a wide range of cyclic dipeptides using aminoacylated tRNAs as substrates. Histidine-containing cyclic dipeptides have important biological activities as anticancer and neuroprotective molecules. Out of the 120 experimentally validated CDPS members, only two...

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Detalles Bibliográficos
Autores principales: Sutherland, Emmajay, Harding, Christopher John, Czekster, Clarissa Melo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613923/
https://www.ncbi.nlm.nih.gov/pubmed/36518199
http://dx.doi.org/10.1038/s42004-022-00715-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613923/
https://www.ncbi.nlm.nih.gov/pubmed/36518199
http://dx.doi.org/10.1038/s42004-022-00715-2

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