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Frequent Aneuploidy in Primary Human T Cells after CRISPR-Cas9 cleavage
Multiple clinical trials of allogeneic T cell therapy use site-specific nucleases to disrupt T cell receptor (TCR) and other genes (1–6). Here, using single-cell RNA sequencing, we investigated genome editing outcomes in primary human T cells transfected with CRISPR-Cas9 and guide RNAs targeting gen...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613940/ https://www.ncbi.nlm.nih.gov/pubmed/35773341 http://dx.doi.org/10.1038/s41587-022-01377-0 |